X0407 4 2023-06-26 0 0001863127 Tyra Biosciences, Inc. TYRA 0001880946 Bensen Daniel C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 0 1 0 0 Chief Operating Officer 1 Common Stock 2023-06-26 4 M 0 17232 0.61 A 545213 D Common Stock 2023-06-26 4 S 0 10862 16.4916 D 534351 D Common Stock 2023-06-26 4 S 0 6370 17.236 D 527981 D Common Stock 2023-06-27 4 M 0 16028 0.61 A 544009 D Common Stock 2023-06-27 4 S 0 7893 16.73 D 536116 D Common Stock 2023-06-27 4 S 0 8135 17.0897 D 527981 D Common Stock 2023-06-28 4 M 0 13524 0.61 A 541505 D Common Stock 2023-06-28 4 S 0 13524 16.906 D 527981 D Stock Option (Right to Buy) 0.61 2023-06-26 4 M 0 17232 0.00 D 2030-01-26 Common Stock 17232 211830 D Stock Option (Right to Buy) 0.61 2023-06-27 4 M 0 16028 0.00 D 2030-01-26 Common Stock 16028 195802 D Stock Option (Right to Buy) 0.61 2023-06-28 4 M 0 13524 0.00 D 2030-01-26 Common Stock 13524 182278 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.01 to $17.005. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $17.02 to $17.69. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.01 to $17.01. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $17.02 to $17.20. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.50 to $17.09. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter. /s/ Ali D. Fawaz, Attorney-in-Fact 2023-06-28