X0407 4 2023-06-16 0 0001863127 Tyra Biosciences, Inc. TYRA 0001711463 Harris Todd C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 1 1 0 0 Chief Executive Officer 1 Common Stock 2023-06-16 4 S 0 3316 16.49 D 1697960 D Common Stock 2023-06-16 4 S 0 50838 17.06 D 1647122 D Common Stock 2023-06-16 4 S 0 600 18.50 D 1646522 D Common Stock 2023-06-20 4 S 0 1300 16.5333 D 1645222 D Common Stock 2023-06-21 4 S 0 4629 16.119 D 1640593 D Common Stock 2023-06-21 4 S 0 14027 17.7057 D 1626566 D Common Stock 2023-06-21 4 S 0 1100 18.1809 D 1625466 D The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022. Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.00 to $16.97. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $17.00 to $17.98. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $18.00 to $19.00. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.04 to $16.82. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.00 to $16.905. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $17.075 to $18.035. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $18.11 to $18.395. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. /s/ Ali D. Fawaz, Attorney-in-Fact 2023-06-21