X0306 4 2022-09-06 0 0001863127 Tyra Biosciences, Inc. TYRA 0001603563 van den Boom Esther C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 0 1 0 0 Chief Financial Officer Common Stock 2022-03-15 5 A 0 E 1800 8.5255 A 120445 D Common Stock 118645 I See footnote Stock Option (Right to Buy) 7.14 2022-09-06 4 A 0 105000 0.00 A 2032-09-05 Common Stock 105000 105000 D Stock Option (Right to Buy) 7.14 2022-09-06 4 A 0 89054 0.00 A 2032-09-05 Common Stock 89054 89054 D These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan. Represents shares held by van den Boom Ventures LLC, of which the spouse of the Reporting Person is the managing member. 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date. 1/36th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date. /s/ Ali D. Fawaz, Attorney-in-Fact 2022-09-08