X0206 3 2022-03-01 0 0001863127 Tyra Biosciences, Inc. TYRA 0001908071 Healy John Stephen C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 0 1 0 0 General Counsel and Secretary Stock Option (Right to Buy) 2.25 2021-03-09 Common Stock 51948 D Stock Option (Right to Buy) 10.75 2031-06-23 Common Stock 134937 D Stock Option (Right to Buy) 24.15 2031-11-01 Common Stock 83626 D Stock Option (Right to Buy) 24.15 2031-11-01 Common Stock 7964 D Stock Option (Right to Buy) 24.15 2031-11-01 Common Stock 7964 D 1/48th of the shares subject to the option vest monthly following February 26, 2021, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date. 25% of the shares subject to the option shall vest on March 5, 2022, and 1/48th of the shares subject to the option vest monthly thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date. 1/48th of the shares subject to the option vest monthly following November 2, 2021, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date. The option vests based on achievement of a performance objective. /s/ John Stephen Healy 2022-03-03