X0306 4 2021-09-17 0 0001863127 Tyra Biosciences, Inc. TYRA 0001207792 MORE ROBERT J C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 1 0 0 0 Common Stock 2021-09-17 4 C 0 3811117 A 3924046 I See footnote Common Stock 2021-09-17 4 P 0 156250 16.00 A 4080296 I See footnote Series A Preferred Stock 2021-09-17 4 C 0 1212122 0.00 D Common Stock 3148365 0 I See footnote Series B Preferred Stock 2021-09-17 4 C 0 255160 0.00 D Common Stock 662752 0 I See footnote On September 17, 2021, each share of Series A Preferred Stock and each share of Series B Preferred Stock converted into Common Stock of the Issuer at a ratio of 1-for-2.5974 without payment of further consideration upon closing of the initial public offering of the Issuer's common stock. The shares had no expiration date. These securities are held directly by Alta Partners NextGen Fund II, L.P. (the "APNG II"). The Reporting Person is a managing director of the general partner of APNG II and shares voting and investment control with respect to the shares held by APNG II. The Reporting Person disclaims beneficial ownership of all shares held by APNG II, except to the extent of his pecuniary interest therein. /s/ John Healy, Attorney-in Fact 2021-09-17