X0306 4 2021-09-17 0 0001863127 Tyra Biosciences, Inc. TYRA 0001381980 Kjellson Nina S C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 1 0 0 0 Common Stock 2021-09-17 4 C 0 3936595 A 3963595 I By Canaan XI L.P. Common Stock 2021-09-17 4 C 0 473396 A 473396 I By 2020+ Co-Investment L.P. - Series 7 Series A Preferred Stock 2021-09-17 4 C 0 1333334 0.00 D Common Stock 3463201 0 I By Canaan XI L.P. Series B Preferred Stock 2021-09-17 4 C 0 182257 0.00 D Common Stock 473394 0 I By Canaan XI L.P. Series B Preferred Stock 2021-09-17 4 C 0 182258 0.00 D Common Stock 473396 0 I By 2020+ Co-Investment L.P. - Series 7 On September 17, 2021, each share of Series A Preferred Stock and each share of Series B Preferred Stock converted into Common Stock of the Issuer at a ratio of 1-for-2.5974 without payment of further consideration upon closing of the initial public offering of the Issuer's common stock. The shares had no expiration date. The sole general partner of Canaan XI L.P. ("Canaan XI") is Canaan Partners XI LLC ("Canaan XI GP"), which may be deemed to have sole voting, investment and dispositive power with respect to the shares held by Canaan XI. Canaan XI GP disclaims Section 16 beneficial ownership of the securities held by Canaan XI, except to the extent of its pecuniary interest therein, if any. The sole general partner of Canaan 2020+ Co-Investment L.P. - Series 7 (the "Canaan Series 7") is Canaan Partners 2020+ Co-Investment LLC ("Canaan 2020+ GP"), which may be deemed to have sole voting, investment and dispositive power with respect to the shares held by Canaan Series 7. Canaan 2020+ GP disclaims Section 16 beneficial ownership of the securities held by Canaan Series 7, except to the extent of its pecuniary interest therein, if any. /s/ John Healy, Attorney-in Fact 2021-09-17