X0508 4 2024-02-06 0001863127 Tyra Biosciences, Inc. TYRA 0001465837 Boxer Capital, LLC 12860 EL CAMINO REAL SUITE 300 SAN DIEGO CA 92130 true See Remarks 0001465836 Boxer Asset Management Inc. CAY HOUSE, EP TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE C5 N7776 BAHAMAS true See Remarks 0001015747 LEWIS JOSEPH CAY HOUSE, EP TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE C5 N7776 BAHAMAS true See Remarks 0001468223 MVA Investors, LLC 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO CA 92130 true See Remarks 0001465914 Davis Aaron I. 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO CA 92130 true See Remarks false Common Stock 2024-02-06 4 A 0 63412 13.01 A 85939 I See Footnote Common Stock 6448359 D Warrant (right to purchase) 0.001 2024-02-06 4 A 0 705280 13.009 A Common Stock 705280 705280 D These securities are owned directly by MVA Investors, LLC ("MVA Investors"). Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each reporting person other than MVA Investors disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any. These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. ("Boxer Management") is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Management. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any. These Warrants are exercisable immediately (subject to any applicable beneficial ownership limitation) and do not have an expiration date. The reporting persons may be deemed members of a group that beneficially owns more than 10% of the outstanding shares of the outstanding shares of Tyra Biosciences, Inc. common stock ("Common Stock"), par value $0.0001 per share By: /s/ Aaron I. Davis, Chief Executive Officer, Boxer Capital, LLC 2024-02-08 By: /s/ Aaron I. Davis, Chief Executive Officer, MVA Investors, LLC 2024-02-08 By: /s/ Paul Higgs, Director, Boxer Asset Management Inc. 2024-02-08 By: /s/ Joseph C. Lewis 2024-02-08 By: /s/ Aaron I. Davis 2024-02-08