X0306 4 2022-10-31 0 0001826457 Monte Rosa Therapeutics, Inc. GLUE 0001862930 Janku Filip MONTE ROSA THERAPEUTICS, INC. 645 SUMMER STREET, SUITE 102 BOSTON MA 02210 0 1 0 0 Chief Medical Officer Stock Option (Right to Buy) 7.56 2022-10-31 4 A 0 36000 0.00 A 2032-10-02 Common Stock 36000 36000 D On October 3, 2022, the Reporting Person was granted an option to purchase 36,000 shares of Common Stock, subject to the satisfaction of certain performance criteria. On October 31, 2022, the performance criteria underlying such shares were met. The shares underlying this option shall vest in full on April 30, 2024, subject to the Reporting Person's continued service on such date. /s/ Ajim Tamboli, Attorney-in-Fact 2022-11-01