X0306 4 2022-01-04 0 0001861560 Nuvalent, Inc. NUVL 0001862148 Noci Darlene C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 0 1 0 0 See Remarks Stock Option (Right to Buy) 18.93 2022-01-04 4 A 0 55800 0.00 A 2032-01-04 Common Stock 55800 55800 D The shares underlying this option vest as follows: 25% of the shares vest on January 4, 2023, and the remainder vest over the next three years in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. SVP of Product Development & Regulatory Affairs /s/ Alexandra Balcom, attorney-in-fact 2022-01-05