X0508 4 2025-11-17 0001861560 Nuvalent, Inc. NUVL 0001862147 Balcom Alexandra C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 false true false false Chief Financial Officer true Class A Common Stock 2025-11-17 4 M false 6875 6.89 A 68609 D Class A Common Stock 2025-11-17 4 M false 13125 72.35 A 81734 D Class A Common Stock 2025-11-17 4 S false 3609 93.80 D 78125 D Class A Common Stock 2025-11-17 4 S false 3266 95.12 D 74859 D Class A Common Stock 2025-11-17 4 S false 4496 100.58 D 70363 D Class A Common Stock 2025-11-17 4 S false 3194 102.13 D 67169 D Class A Common Stock 2025-11-17 4 S false 5055 103.27 D 62114 D Class A Common Stock 2025-11-17 4 S false 380 103.68 D 61734 D Class A Common Stock 2025-11-18 4 M false 729 72.35 A 62463 D Class A Common Stock 2025-11-18 4 S false 220 103.61 D 62243 D Class A Common Stock 2025-11-18 4 S false 509 104.54 D 61734 D Stock Option (Right to Buy) 6.89 2025-11-17 4 M false 6875 0.00 D 2031-04-29 Class A Common Stock 6875 29101 D Stock Option (Right to Buy) 72.35 2025-11-17 4 M false 13125 0.00 D 2034-01-05 Class A Common Stock 13125 34375 D Stock Option (Right to Buy) 72.35 2025-11-18 4 M false 729 0.00 D 2034-01-05 Class A Common Stock 729 33646 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 12, 2024. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.73 to $94.38, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, Nuvalent, Inc. or any security holder of Nuvalent, Inc., upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (9) of this Form 4. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.93 to $95.58, inclusive. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.11 to $101.07, inclusive. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $101.57 to $102.47, inclusive. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $102.60 to $103.54, inclusive. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $103.65 to $103.79, inclusive. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $103.14 to $103.96, inclusive. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $104.25 to $105.12, inclusive. The shares underlying this option vest as follows: 25% of the shares vested on April 29, 2022, and the remainder have vested or shall vest over the three years thereafter in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. The shares underlying this option have vested or shall vest over the four years following January 5, 2024 in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. /s/ Nathan N. McConarty, attorney-in-fact 2025-11-19