X0306 4 2021-11-16 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001861926 SAHA SAURABH C/O CENTESSA PHARMACEUTICALS PLC 3RD FL., 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 1 1 0 0 Chief Executive Officer Ordinary Shares 2021-11-16 4 P 0 23000 12.2814 A 23000 I By trust The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.95 to $12.59, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. These shares are held directly in a trust, for which the reporting person and his spouse serve as trustees. /s/ Marella Thorell, attorney-in-fact 2021-11-18