X0306 4 2022-05-17 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001861878 YVER ANTOINE C/O CENTESSA PHARMACEUTICALS PLC 3RD FL., 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 0 1 0 0 EVP & Chairman of Development Ordinary Shares 2022-05-17 4 S 0 20222 5.4214 D 813675 D Ordinary Shares 2022-05-18 4 S 0 64778 5.0959 D 748897 D The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of the restricted shares and does not represent a discretionary trade by the Reporting Person. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.26 to $5.55, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.00 to $5.47, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. /s/ Marella Thorell, attorney-in-fact 2022-05-19