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    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001861657</cik>
        <entityName>Canton Strategic Holdings, Inc.</entityName>
        <issuerAddress>
            <street1>34 SHREWSBURY AVE.</street1>
            <city>RED BANK</city>
            <stateOrCountry>NJ</stateOrCountry>
            <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
            <zipCode>07701</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(732) 889-3111</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Hillstream BioPharma, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Tharimmune, Inc.</previousName>
            <previousName>Tharimmune, Inc</previousName>
            <previousName>Hillstream BioPharma Inc.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <lastName>Wendland</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>34 Shrewsbury Ave.</street1>
                <city>Red Bank</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>07701</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jacob</firstName>
                <lastName>Asbury</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>34 Shrewsbury Ave.</street1>
                <city>Red Bank</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>07701</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Financial Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Angela</firstName>
                <lastName>Radkowski</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>34 Shrewsbury Ave.</street1>
                <city>Red Bank</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>07701</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Operating Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <lastName>Toomey</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>34 Shrewsbury Ave.</street1>
                <city>Red Bank</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>07701</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>President</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Vincent</firstName>
                <lastName>LoPriore</lastName>
            </relatedPersonName>
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                <street1>34 Shrewsbury Ave.</street1>
                <city>Red Bank</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>07701</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Sireesh</firstName>
                <lastName>Appajosyula</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>34 Shrewsbury Ave.</street1>
                <city>Red Bank</city>
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                <zipCode>07701</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Clay</firstName>
                <lastName>Kahler</lastName>
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                <street1>34 Shrewsbury Ave.</street1>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gary</firstName>
                <lastName>Stetz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>34 Shrewsbury Ave.</street1>
                <city>Red Bank</city>
                <stateOrCountry>NJ</stateOrCountry>
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                <zipCode>07701</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jill</firstName>
                <lastName>Sommers</lastName>
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            <relatedPersonAddress>
                <street1>34 Shrewsbury Ave.</street1>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <lastName>Wiley</lastName>
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                <street1>34 Shrewsbury Ave.</street1>
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                <stateOrCountry>NJ</stateOrCountry>
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                <zipCode>07701</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        </relatedPersonInfo>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2025-07-23</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>President Street Global LLC</recipientName>
                <recipientCRDNumber>000318377</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>34 Shrewsbury Ave</street1>
                    <city>Red Bank</city>
                    <stateOrCountry>NJ</stateOrCountry>
                    <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                    <zipCode>07701</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1740000</totalOfferingAmount>
            <totalAmountSold>1740000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>13</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>121800</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Received placement agent warrants to purchase 52,128 shares of common stock with a strike price of $1.66.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Canton Strategic Holdings, Inc.</issuerName>
                <signatureName>/s/ Mark Wendland</signatureName>
                <nameOfSigner>Mark Wendland</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2026-04-14</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
