144 0002029477 XXXXXXXX LIVE 0001861560 NUVALENT, INC. 001-40671 One Broadway 14th Floor Cambridge MA 02142 (857)-357-7000 Henry E. Pelish Officer Class A Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

2111 261358.43 73562661 07/09/2026 NASDAQ Class A Common Stock 07/09/2026 Restricted Stock Unit Vesting Issuer N 2111 07/09/2026 Equity Compensation N Henry Pelish

One Broadway, 14th Floor Cambridge MA 02142

Class A Common Stock 04/09/2026 3093 323169.86 The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units. These sales do not represent discretionary trades by the Reporting Person. 07/09/2026 12/06/2023 /s/ Henry E. Pelish