Accrued Expenses - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2026	Dec. 31, 2025
Accrued Liabilities, Current [Abstract]
Accrued clinical and other research and development	$ 39,202	$ 30,235
Accrued manufacturing	7,896	10,976
Accrued employee compensation and benefits	8,213	16,935
Accrued other and other current liabilities	3,604	2,867
Total accrued expenses and other current liabilities	$ 58,915	$ 61,013