X0407 4 2023-05-15 0 0001861560 Nuvalent, Inc. NUVL 0001868741 Miller Deborah Ann C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 0 1 0 0 Chief Legal Officer 1 Class A Common Stock 2023-05-15 4 M 0 2000 6.89 A 2000 D Class A Common Stock 2023-05-15 4 S 0 502 40.31 D 1498 D Class A Common Stock 2023-05-15 4 S 0 1498 40.89 D 0 D Stock Option (Right to Buy) 6.89 2023-05-15 4 M 0 2000 0.00 D 2031-04-29 Class A Common Stock 2000 206138 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 22, 2021. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.53 to $40.52, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, Nuvalent, Inc. or any security holder of Nuvalent, Inc., upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) of this Form 4. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.55 to $41.30, inclusive. The shares underlying this option vest as follows: 25% of the shares vested on April 15, 2022, and the remainder have vested or shall vest over the next three years thereafter in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. /s/ Deborah Ann Miller 2023-05-17