X0206 3 2022-10-04 0 0001861560 Nuvalent, Inc. NUVL 0001664204 Meyers Michael L. C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 1 0 0 0 Stock Option (Right to Buy) 6.89 2031-04-29 Class A Common Stock 8361 D The shares underlying this option vest as follows: 25% of the shares vested on January 16, 2022 and the remainder have vested or shall vest over the next three years thereafter in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. Exhibit List: Exhibit 24 - Power of Attorney /s/ Deborah A. Miller, attorney-in-fact 2022-10-06