X0306 4 2022-06-16 0 0001861560 Nuvalent, Inc. NUVL 0001862149 Pearlberg Joseph C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 1 0 0 0 Stock Option (Right to Buy) 9.36 2022-06-16 4 A 0 20000 0.00 A 2032-06-16 Class A Common Stock 20000 20000 D The Reporting Person, an employee of Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P. The shares underlying this option shall vest in full on the earlier of June 16, 2023 or the date of Nuvalent, Inc.'s next annual meeting of stockholders, subject to continued service to Nuvalent, Inc. through the applicable vesting date. Exhibit List: Exhibit 24 - Limited Power of Attorney /s/ Deborah A. Miller, attorney-in-fact 2022-06-21