The following table describes for the quarterly period ended December 31, 2023, each trading arrangement for the sale or purchase of Company securities adopted or terminated by our directors and officers that is either (1) a contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) (a Rule 10b5-1 trading arrangement) or (2) a “non-Rule 10b5-1 trading arrangement” (as defined in Item 408(c) of Regulation S-K):


Name (Title)	Action Taken (Date of Action)	Type of Trading Arrangement	Nature of Trading Arrangement	Duration of Trading Arrangement	Aggregate Number of Securities
James Porter (Chief Executive Officer)	Adoption (December 6, 2023)	Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all RSU equity awards that have been or may be granted	Sale	Until final settlement of any covered RSU	Indeterminable(1)
Alexandra Balcom (Chief Financial Officer)	Adoption (December 6, 2023)	Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all RSU equity awards that have been or may be granted	Sale	Until final settlement of any covered RSU	Indeterminable(1)
Alexandra Balcom (Chief Financial Officer)	Adoption (December 28, 2023)	Rule 10b5-1 trading arrangement	Sale	Until December 20, 2024, or such earlier date upon which all transactions are completed or expire without execution	Up to 60,000 shares of Class A common stock
Deborah Miller (Chief Legal Officer)	Adoption (December 6, 2023)	Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all RSU equity awards that have been or may be granted	Sale	Until final settlement of any covered RSU	Indeterminable(1)
Deborah Miller (Chief Legal Officer)	Adoption (December 27, 2023)	Rule 10b5-1 trading arrangement	Sale	Until December 6, 2024, or such earlier date upon which all transactions are completed or expire without execution	Up to 70,000 shares of Class A common stock
Christopher Turner (Chief Medical Officer)	Adoption (December 6, 2023)	Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all RSU equity awards that have been or may be granted	Sale	Until final settlement of any covered RSU	Indeterminable(1)
Darlene Noci (Chief Development Officer)	Adoption (December 6, 2023)	Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all RSU equity awards that have been or may be granted	Sale	Until final settlement of any covered RSU	Indeterminable(1)
Darlene Noci (Chief Development Officer)	Adoption (December 21, 2023)	Rule 10b5-1 trading arrangement	Sale	Until November 29, 2024, or such earlier date upon which all transactions are completed or expire without execution	Up to 45,000 shares of Class A common stock
Emily Conley (Director)	Adoption (December 13, 2023)	Rule 10b5-1 trading arrangement	Sale	Until September 5, 2024, or such earlier date upon which all transactions are completed or expire without execution	Up to 40,000 shares of Class A common stock
Matthew Shair (Director)	Adoption (December 21, 2023)	Rule 10b5-1 trading arrangement	Sale	Until February 26, 2025, or such earlier date upon which all transactions are completed or expire without execution	Up to 324,000 shares of Class A common stock

(1) The number of shares subject to covered restricted stock units (RSUs) that will be sold to satisfy applicable tax withholding obligations upon vesting is unknown as the number will vary based on the extent to which vesting conditions are satisfied, the market price of the Company’s common stock at the time of settlement and the potential future grant of additional RSUs subject to this arrangement. This trading arrangement, which applies to RSUs whether vesting is based on the passage of time and/or the achievement of performance goals, provides for the automatic sale of shares that would otherwise be issuable on each settlement date of a covered RSU in an amount sufficient to satisfy the applicable withholding obligation, with the proceeds of the sale delivered to the Company in satisfaction of the applicable withholding obligation.

Trading Arrangements, by Individual

Title

Chief Executive Officer

Adoption Date

December 6, 2023

Trading Arrangements, by Individual

Title

Chief Medical Officer

Adoption Date

December 6, 2023

Trading Arrangements, by Individual

Title