X0306 4 2021-07-28 0 0001861560 Nuvalent, Inc. NUVL 0001862149 Pearlberg Joseph C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 1 0 0 0 Stock Option (Right to Buy) 17.00 2021-07-28 4 A 0 43000 0.00 A 2031-07-28 Class A Common Stock 43000 43000 D The option will vest and become exercisable as follows: 1/3 of the option will vest on July 29, 2022 and the remainder will vest over the next two years in equal monthly installments, subject to the Reporting Person's continued service to the Company through the applicable vesting date. The Reporting Person, an employee of Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P. /s/ Alexandra Balcom, attorney-in-fact 2021-07-30