X0306 4 2021-05-17 0 0001299130 PACIFIC BIOSCIENCES OF CALIFORNIA, INC. PACB 0001860876 Farmer Michele PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 1305 O'BRIEN DRIVE MENLO PARK CA 94025 0 1 0 0 Chief Accounting Officer Common Stock 2021-05-17 4 A 0 40000 0.00 A 40000 D Stock Option (right to buy) 23.39 2021-05-17 4 A 0 80000 0.00 A 2022-05-17 2031-05-17 Common Stock 80000 80000 D Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on May 17 of each of 2022, 2023, 2024, and 2025, provided that the Reporting Person continues to serve through each vesting date. 1/4 of the shares subject to the option will vest on the one year anniversary of the date of grant, and the balance of shares will vest monthly thereafter over the next three years, provided that the Reporting Person continues to serve through each vesting date. /s/ Brett Atkins, Attorney-in-fact 2021-05-19