X0306 4 2021-04-30 0 0001404644 Neoleukin Therapeutics, Inc. NLTX 0001859997 Patel Priti C/O NEOLEUKIN THERAPEUTICS, INC. 188 EAST BLAINE STREET, #450 SEATTLE WA 98102 0 1 0 0 Chief Medical Officer Restricted Stock Units 0.00 2021-04-30 4 A 0 20000 0.00 A Common Stock 20000 20000 D Stock Option (Right to Buy) 12.49 2021-04-30 4 A 0 475000 0.00 A 2031-04-30 Common Stock 475000 475000 D Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock upon settlement for no consideration. The RSUs will vest as to 1/2 of the total number of shares underlying the award on each of April 30, 2022 and April 30, 2023, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The RSUs do not expire; these securities either vest and settle or are canceled prior to the vesting date. The option vests as to 1/4 of the total shares on April 30, 2022, and then 1/48 of the total shares will vest monthly thereafter, subject to the Reporting Person's provision of service to the Issuer on each vesting date. /s/ Kris McGrew, as Attorney-in-Fact for Priti Patel 2021-05-04