X0306 4 2022-04-26 0 0001858848 Tenaya Therapeutics, Inc. TNYA 0001553333 Hoey Timothy C/O TENAYA THERAPEUTICS, INC. 171 OYSTER POINT BLVD., 5TH FLOOR SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Scientific Officer Common Stock 2022-04-26 4 S 0 1353 10.13 D 198646 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 12, 2022. Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $10.02 to $10.33. Reporting Person undertakes to provide Tenaya Therapeutics, Inc., any security holder of Tenaya Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4. /s/ Jennifer Drimmer Rokovich, Attorney in Fact 2022-04-28