X0306 4 2022-02-15 0 0001858848 Tenaya Therapeutics, Inc. TNYA 0001553333 Hoey Timothy C/O TENAYA THERAPEUTICS, INC. 171 OYSTER POINT BLVD., 5TH FLOOR SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Scientific Officer Stock Option (Right to buy) 15.19 2022-02-15 4 A 0 168000 0.00 A 2022-03-15 2032-02-14 Common Stock 168000 168000 D Option granted pursuant to the Tenaya Therapeutics, Inc. 2021 Equity Incentive Plan. Option will vest as to 1/48th of the total number of shares subject to the option on the one (1) month anniversary of the Transaction Date and 1/48th of the total number of shares subject to the option on each monthly anniversary thereafter, subject to the Reporting Person continuing to be a service provider to the Issuer through each applicable vesting date. /s/ Jennifer Drimmer Rokovich, Attorney-in-Fact 2022-02-17