X0306 4 2021-08-03 0 0001858848 Tenaya Therapeutics, Inc. TNYA 0001534265 Casdin Partners Master Fund, L.P. 1350 AVENUE OF THE AMERICAS SUITE 2600 NEW YORK NY 10019 0 0 1 0 0001823061 Casdin Private Growth Equity Fund, L.P. 1350 AVENUE OF THE AMERICAS SUITE 2600 NEW YORK NY 94080 0 0 1 0 0001534261 Casdin Capital, LLC 1350 AVENUE OF THE AMERICAS SUITE 2600 NEW YORK NY 10019 0 0 1 0 0001864554 CASDIN PRIVATE GROWTH EQUITY FUND GP, LLC 1350 AVENUE OF THE AMERICAS SUITE 2600 NEW YORK NY 10019 0 0 1 0 Common Stock 2021-08-03 4 C 0 2374849 0.00 A 2374849 I See Footnotes Common Stock 2021-08-03 4 P 0 850000 15.00 A 3224849 I See Footnotes Common Stock 2021-08-03 4 C 0 361969 0.00 A 361969 I See Footnotes Series B Preferred Stock 0.00 2021-08-03 4 C 0 2012880 D Common Stock 2012880 0 I See Footnotes Series C Preferred Stock 0.00 2021-08-03 4 C 0 361969 D Common Stock 361969 0 I See Footnotes Series C Preferred Stock 0.00 2021-08-03 4 C 0 361969 D Common Stock 361969 0 I See Footnotes These shares are held directly by Casdin Partners Master Fund, L.P.(CPMF). Casdin Capital, LLC is the investment advisor to CPMF and CPGEF. Casdin Partners GP, LLC is the general partner of CPMF. Casdin Private Growth Equity Fund GP, LLC is the general partner of CPGEF. The Reporting Person is the managing member of Casdin Capital, LLC, Casdin Partners GP, LLC and Casdin Private Growth Equity Fund GP, LLC and may be deemed to have voting and investment power with respect to the shares. The Reporting Person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein, if any. These shares are held directly by Casdin Private Growth Equity Fund, L.P. (CPGEF). Each share of Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock automatically converted into one share of common stock immediately prior to the completion of the Issuer's initial public offering, and had no expiration date. Eli Casdin, managing member of Casdin Partners GP, LLC, the general partner of Casdin Partners Master Fund, LP 2021-08-03 Eli Casdin, managing member of Casdin Partners GP, LLC, the general partner of Casdin Private Growth Equity Fund, LP 2021-08-03 Eli Casdin, managing member of Casdin Capital, LLC 2021-08-03 Eli Casdin, managing member of Casdin Private Growth Equity Fund GP, LLC 2021-08-03