X0206 3 2021-07-29 0 0001858848 Tenaya Therapeutics, Inc. TNYA 0001868501 Srivastava Deepak C/O TENAYA THERAPEUTICS, INC. 171 OYSTER POINT BLVD., 5TH FLR SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 191666 D Common Stock 141666 I See Footnotes Stock Option (Right to Buy) 2.70 2029-12-06 Common Stock 37500 D These shares are held directly by The J. David Gladstone Institutes for which the Reporting Person serves as President. The Reporting Person may be deemed to have voting and investment control over the shares. The Reporting Person disclaims beneficial ownership of these shares. This report shall not be deemed an admission that the Reporting Person is the beneficial owner of any of the shares held by The J. David Gladstone Institutes for Section 16 or any other purpose. 1/48th of the shares subject to the option granted on December 6, 2019 became vested and exercisable as of November 6, 2019 and 1/48th of the shares subject to the option shall vest monthly thereafter, provided that the Reporting Person remains a service provider to the issuer on each such vest date. Date set forth above represents the effective date of the Issuer's initial public offering /s/ Leone Patterson Attorney-in-Fact for Deepak Srivastava 2021-07-29