X0206 3 2021-07-29 0 0001858848 Tenaya Therapeutics, Inc. TNYA 0001534264 Casdin Eli C/O TENAYA THERAPEUTICS, INC. 171 OYSTER POINT BLVD., 5TH FLR. SOUTH SAN FRANCISCO CA 94080 1 0 1 0 Series B Preferred Stock 0.00 Common Stock 2012880 I See Footnotes Series C Preferred Stock 0.00 Common Stock 361969 I See Footnotes Series C Preferred Stock 0.00 Common Stock 361969 I See Footnotes Each share of Series B Preferred Stock and Series C Preferred Stock will automatically convert into one share of common stock immediately prior to the completion of the Issuer's initial public offering, and has no expiration date. These shares are held directly by Casdin Partners Master Fund, L.P.(CPMF). Casdin Capital, LLC is the investment advisor to CPMF and CPGEF. Casdin Partners GP, LLC is the general partner of CPMF. Casdin Private Growth Equity Fund GP, LLC is the general partner of CPGEF. The Reporting Person is the managing member of Casdin Capital, LLC, Casdin Partners GP, LLC and Casdin Private Growth Equity Fund GP, LLC and may be deemed to have voting and investment power with respect to the shares. The Reporting Person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein, if any. The Reporting Person is a member of the Board of Directors of the Issuer. This report shall not be deemed an admission that the reporting person is the beneficial owner of any of the shares held by CPMF or CPGEF for Section 16 or any other purpose. These shares are held directly by Casdin Private Growth Equity Fund, L.P. (CPGEF). Date set forth above represents the effective date of the Issuer's initial public offering /s/Leone Patterson Attorney-in-Fact for Eli Casdin 2021-07-29