<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001868494</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001858848</issuerCik>
<issuerName>Tenaya Therapeutics, Inc.</issuerName>
<secFileNumber>001-40656</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">171 Oyster Point Boulevard</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 500</street2>
<city xmlns="http://www.sec.gov/edgar/common">South San Francisco</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">94080</zipCode>
</issuerAddress>
<issuerContactPhone>(650)-825-6990</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Whittemore Tingley</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley Smith Barney</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">Operations Department</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">2000 Westchester Ave</street2>
<city xmlns="http://www.sec.gov/edgar/common">Purchase</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">10577-2530</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>5160</noOfUnitsSold>
<aggregateMarketValue>3318.72</aggregateMarketValue>
<noOfUnitsOutstanding>213744535</noOfUnitsOutstanding>
<approxSaleDate>02/17/2026</approxSaleDate>
<securitiesExchangeName>Nasdaq Global Select</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>02/17/2026</acquiredDate>
<natureOfAcquisitionTransaction>Restricted Stock Unit</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>13750</amountOfSecuritiesAcquired>
<paymentDate>02/17/2026</paymentDate>
<natureOfPayment>N/A</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<noticeSignature>
<noticeDate>02/17/2026</noticeDate>
<signature>/s/ Whittemore Tingley</signature>
</noticeSignature>
</formData>
</edgarSubmission>
