X0306 4 2023-02-28 0 0001850838 Omega Therapeutics, Inc. OMGA 0001858760 McCauley Thomas C/O OMEGA THERAPEUTICS, INC. 20 ACORN PARK DRIVE CAMBRIDGE MA 02140 0 1 0 0 Chief Scientific Officer Option (Right to Buy) 6.46 2023-02-28 4 A 0 55000 0.00 A 2033-02-27 Common Stock 55000 55000 D The options vest and become exercisable with respect to 25% of the underlying shares on February 28, 2024 and in equal quarterly installments thereafter such that the option will become fully vested and exercisable on February 28, 2027, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Barbara Chan as Attorney-in-Fact for Thomas McCauley, Ph.D. 2023-03-02