X0306 4 2022-10-27 0 0001850838 Omega Therapeutics, Inc. OMGA 0001858760 McCauley Thomas C/O OMEGA THERAPEUTICS, INC. 20 ACORN PARK DRIVE CAMBRIDGE MA 02140 0 1 0 0 Chief Scientific Officer Option (Right to Buy) 5.27 2022-10-27 4 A 0 55000 0.00 A 2032-10-26 Common Stock 55000 55000 D The options vest and become exercisable as to 25% of the underlying shares on October 27, 2023 and as to 6.25% of the underlying shares upon the Reporting Person's completion of each three full months of continued service to the Issuer thereafter, such that the option will be fully vested and exercisable on October 27, 2026. /s/ Barbara Chan as Attorney-in-Fact for Thomas McCauley, Ph.D 2022-10-28