X0306 4 2022-03-09 0 0001850838 Omega Therapeutics, Inc. OMGA 0001858748 Sawhney Roger C/O OMEGA THERAPEUTICS, INC. 20 ACORN PARK DRIVE CAMBRIDGE MA 02140 0 1 0 0 Chief Financial Officer Option (Right to Buy) 10.34 2022-03-09 4 A 0 60000 0.00 A 2032-03-08 Common Stock 60000 60000 D The options vest and become exercisable with respect to 25% of the underlying shares on March 9, 2023 and in equal quarterly installments thereafter such that the option will become fully vested and exercisable on March 9, 2026, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Barbara Chan as Attorney-in-fact for Roger Sawhney 2022-03-11