144 0001858176 XXXXXXXX LIVE 0001400118 SAGIMET BIOSCIENCES INC 001-41742 950 Tower Lane, Suite 1500 Foster City CA 94404 6505618600 GEORGE KEMBLE Director Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

350987 3257159.36 61591159 08/14/2026 NASDAQ Common 08/14/2026 Exercise of Stock Options Issuer N 350987 08/14/2026 Cash N 10b5-1 Sales for GEORGE KEMBLE

950 Tower Lane, Suite 1500 Foster City CA 94404

Common 08/11/2026 20206 201146.40 10b5-1 Sales for GEORGE KEMBLE

950 Tower Lane, Suite 1500 Foster City CA 94404

Common 07/20/2026 18844 140529.13 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 08/14/2026 08/21/2025 /s/ George Kemble