<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001858021</cik>
        <entityName>CIS Holdings, Inc.</entityName>
        <issuerAddress>
            <street1>8888 KEYSTONE CROSSING</street1>
            <street2>SUITE 600</street2>
            <city>INDIANAPOLIS</city>
            <stateOrCountry>IN</stateOrCountry>
            <stateOrCountryDescription>INDIANA</stateOrCountryDescription>
            <zipCode>46240</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>317-574-6900</issuerPhoneNumber>
        <jurisdictionOfInc>INDIANA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2021</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Luke</firstName>
                <middleName>A.</middleName>
                <lastName>Phenicie</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8888 Keystone Crossing, Suite 600</street1>
                <city>Indianapolis</city>
                <stateOrCountry>IN</stateOrCountry>
                <stateOrCountryDescription>INDIANA</stateOrCountryDescription>
                <zipCode>46240</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <middleName>M.</middleName>
                <lastName>Eline</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8888 Keystone Crossing, Suite 600</street1>
                <city>Indianapolis</city>
                <stateOrCountry>IN</stateOrCountry>
                <stateOrCountryDescription>INDIANA</stateOrCountryDescription>
                <zipCode>46240</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <lastName>Strang</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>21050 Ashburn Crossing Dr., Suite 145</street1>
                <city>Ashburn</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>20147</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>C.</middleName>
                <lastName>Armstrong</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>21050 Ashburn Crossing Dr., Suite 145</street1>
                <city>Ashburn</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>21047</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeffrey</firstName>
                <lastName>Gordon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>45 Rockefeller Center</street1>
                <street2>630 Fifth Avenue, Suite 400</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10111</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Technology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2022-07-08</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>true</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>27000000</totalOfferingAmount>
            <totalAmountSold>27000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>5</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CIS Holdings, Inc.</issuerName>
                <signatureName>Christopher M. Eline</signatureName>
                <nameOfSigner>Christopher M. Eline</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2022-07-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
