X0306 4 2021-12-15 0 0001785530 Werewolf Therapeutics, Inc. HOWL 0001857795 Leonard Reid C/O WEREWOLF THERAPEUTICS, INC. 1030 MASSACHUSETTS AVENUE, SUITE 210 CAMBRIDGE MA 02138 0 1 0 0 Chief Operating Officer Common Stock 2021-12-15 4 S 0 2865 13.3875 D 122292 I By The Leonard Revocable Living Trust Common Stock 2021-12-15 4 S 0 135 13.9736 D 122157 I By The Leonard Revocable Living Trust The transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 12, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.84 to $13.78, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) of this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.93 to $13.99, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (3) of this Form 4. /s/ Reid Leonard 2021-12-17