The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 21,917 3,140,000 SH   SOLE   3,140,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 24,420 1,733,130 SH   SOLE   1,733,130 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 14,570 3,100,000 SH   SOLE   3,100,000 0 0
ADICET BIO INC COM 007002108 13,024 892,028 SH   SOLE   892,028 0 0
AGENUS INC COM NEW 00847G705 43,148 22,241,417 SH   SOLE   22,241,417 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 72,910 499,900 SH Call SOLE   499,900 0 0
ANAPTYSBIO INC COM 032724106 13,653 672,569 SH   SOLE   672,569 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 6,300 3,000,000 SH   SOLE   3,000,000 0 0
ATYR PHARMA INC COM NEW 002120202 823 290,844 SH   SOLE   290,844 0 0
BEAM THERAPEUTICS INC COM 07373V105 48,388 1,250,000 SH   SOLE   1,250,000 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 48,662 2,900,000 SH   SOLE   2,900,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 54,227 654,365 SH   SOLE   654,365 0 0
CENTURY THERAPEUTICS INC COM 15673T100 7,767 924,641 SH   SOLE   924,641 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 59,993 3,430,110 SH   SOLE   3,430,110 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 19,638 1,053,000 SH   SOLE   1,053,000 0 0
DICE THERAPEUTICS INC COM 23345J104 16,186 1,042,900 SH   SOLE   1,042,900 0 0
DYNE THERAPEUTICS INC COM 26818M108 24,045 3,500,000 SH   SOLE   3,500,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 38,160 6,000,000 SH   SOLE   6,000,000 0 0
FATE THERAPEUTICS INC COM 31189P102 50,006 2,018,005 SH   SOLE   2,018,005 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 27,905 4,050,000 SH   SOLE   4,050,000 0 0
FULCRUM THERAPEUTICS INC COM 359616109 4,900 1,000,000 SH   SOLE   1,000,000 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 4,984 499,400 SH   SOLE   499,400 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 116,512 3,646,690 SH   SOLE   3,646,690 0 0
GRITSTONE BIO INC COM 39868T105 4,162 1,720,000 SH   SOLE   1,720,000 0 0
HOOKIPA PHARMA INC COM 43906K100 8,209 5,035,998 SH   SOLE   5,035,998 0 0
IMMUNOVANT INC COM 45258J102 36,875 9,455,000 SH   SOLE   9,455,000 0 0
INOZYME PHARMA INC COM 45790W108 15,503 3,250,000 SH   SOLE   3,250,000 0 0
IVERIC BIO INC COM 46583P102 43,290 4,500,000 SH   SOLE   4,500,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 78,005 500,000 SH   SOLE   500,000 0 0
JOUNCE THERAPEUTICS INC COM 481116101 12,907 4,259,653 SH   SOLE   4,259,653 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 17,948 1,824,000 SH   SOLE   1,824,000 0 0
KEROS THERAPEUTICS INC COM 492327101 20,433 739,528 SH   SOLE   739,528 0 0
KURA ONCOLOGY INC COM 50127T109 67,784 3,697,969 SH   SOLE   3,697,969 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 64,780 905,000 SH   SOLE   905,000 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 6,431 5,359,000 SH   SOLE   5,359,000 0 0
NKARTA INC COM 65487U108 34,679 2,814,844 SH   SOLE   2,814,844 0 0
NOVOCURE LTD ORD SHS G6674U108 93,220 1,341,300 SH   SOLE   1,341,300 0 0
NURIX THERAPEUTICS INC COM 67080M103 30,866 2,436,164 SH   SOLE   2,436,164 0 0
NUVATION BIO INC COM CL A 67080N101 37,167 11,471,281 SH   SOLE   11,471,281 0 0
PASSAGE BIO INC COM 702712100 5,475 2,320,000 SH   SOLE   2,320,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 2,061 260,500 SH Put SOLE   260,500 0 0
RELMADA THERAPEUTICS INC COM 75955J402 9,495 500,000 SH   SOLE   500,000 0 0
REPARE THERAPEUTICS INC COM 760273102 37,880 2,707,662 SH   SOLE   2,707,662 0 0
SAGE THERAPEUTICS INC COM 78667J108 5,549 171,800 SH   SOLE   171,800 0 0
SCHRODINGER INC COM 80810D103 14,842 562,000 SH   SOLE   562,000 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 11,276 951,580 SH   SOLE   951,580 0 0
TENAYA THERAPEUTICS INC COM 87990A106 2,724 483,836 SH   SOLE   483,836 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 86,760 3,580,700 SH   SOLE   3,580,700 0 0
TRICIDA INC COM 89610F101 26,447 2,732,117 SH   SOLE   2,732,117 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 796 308,393 SH   SOLE   308,393 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 13,540 1,170,290 SH   SOLE   1,170,290 0 0