SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* CMLS Holdings III LLC (Last) (First) (Middle) C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE (Street) NEW YORK NY 10065 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 04/06/2021	3. Issuer Name and Ticker or Trading Symbol CM Life Sciences III Inc. [ CMLT ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Class B common stock	(1)	(1)	Class A common stock	13,700,000(2)	(1)	D(3)

1. Name and Address of Reporting Person* CMLS Holdings III LLC (Last) (First) (Middle) C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE (Street) NEW YORK NY 10065 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* C-LSH III LLC (Last) (First) (Middle) C/O CASDIN CAPITAL, LLC 1350 AVE OF THE AMERICAS, SUITE 2600 (Street) NEW YORK NY 10019 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* M-LSH III LLC (Last) (First) (Middle) C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE (Street) NEW YORK NY 10065 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Casdin Eli (Last) (First) (Middle) C/O CASDIN CAPITAL, LLC 1350 AVE OF THE AMERICAS, SUITE 2600 (Street) NEW YORK NY 10019 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner X Officer (give title below) Other (specify below) Chief Executive Officer

1. Name and Address of Reporting Person* Meister Keith A. (Last) (First) (Middle) C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE (Street) NEW YORK NY 10065 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. The shares of Class B common stock will automatically convert into shares of Class A common stock at the time of the issuer's initial business combination or earlier at the option of the holder as described under the heading "Description of Securities--Founder Shares" in the Issuer's registration statement on Form S-1 (File No. 333-253475) (the "Registration Statement"), on a one-for-one basis, subject to adjustment for stock splits, stock capitalizations, reorganizations, recapitalizations and the like, and certain anti-dilution rights and have no expiration date.

2. The shares of Class B common stock owned by the reporting persons include up to 1,800,000 shares that are subject to forfeiture in the event the underwriters of the offering do not exercise in full their over-allotment option as described in the Registration Statement.

3. CMLS Holdings III LLC is the record holder of the shares reported herein. The Board of Managers of CMLS Holdings III LLC is comprised of Mr. Casdin and Mr. Meister who share voting and investment discretion with respect to the common stock held of record by CMLS Holdings III LLC. C-LSH III LLC and M-LSH III LLC are the members of CMLS Holdings III LLC, and Mr. Casdin and Mr. Meister are the managing members of C-LSH III LLC and M-LSH III LLC, respectively. Each of C-LSH III LLC, M-LSH III LLC and Messrs. Casdin and Meister disclaims beneficial ownership of these shares except to the extent of its or his respective pecuniary interest therein.

Remarks:

See Exhibits 24.1, 24.2, 24.3, 24.4 and 24.5 - Powers of Attorney

	/s/ Brian Emes, as Attorney-in-Fact for CMLS III Holdings LLC	04/06/2021
	/s/ Brian Emes, as Attorney-in-Fact for C-LSH III LLC	04/06/2021
	/s/ Brian Emes, as Attorney-in-Fact for M-LSH III LLC	04/06/2021
	/s/ Brian Emes, as Attorney-in-Fact for Eli Casdin	04/06/2021
	/s/ Brian Emes, as Attorney-in-Fact for Keith A. Meister	04/06/2021
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
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