144 0002065965 XXXXXXXX LIVE 0001855175 Contineum Therapeutics, Inc. 001-42001 3565 General Atomics Court, Suite 200 San Diego CA 92121 8583335280 TIMOTHY WATKINS Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

10833 134437.53 23099173 12/29/2025 NASDAQ Common 12/29/2025 Exercise of Stock Options Issuer N 10833 12/29/2025 Cash Y The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 12/29/2025 09/23/2025 /s/ Timothy Watkins