<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001854864</cik>
        <entityName>Lafayette Square Holding Company, LLC</entityName>
        <issuerAddress>
            <street1>175 SW SEVENTH ST., UNIT 1911</street1>
            <city>Miami</city>
            <stateOrCountry>FL</stateOrCountry>
            <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
            <zipCode>33130</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(786) 598-2089</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Limited Liability Company</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2020</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Damien</firstName>
                <lastName>Dwin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW SEVENTH ST., UNIT 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Edith</firstName>
                <lastName>Cooper</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michaela</firstName>
                <lastName>Edwards</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Forman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Frank</firstName>
                <lastName>Raines</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>George</firstName>
                <lastName>Van Amson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Barton</firstName>
                <lastName>Winokur</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Philip</firstName>
                <lastName>Daniele</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <lastName>Seligmann</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Huy</firstName>
                <lastName>Cao</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Caitlin</firstName>
                <lastName>McLaughlin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ileana</firstName>
                <lastName>Stone</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Satyadeep</firstName>
                <lastName>Patnaik</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Lafayette Square Holding Company, LLC</street1>
                <street2>175 SW Seventh St., Unit 1911</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Banking and Financial Services</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2023-04-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>82,350 Common Units @$100/Common Unit, and warrants to purchase 50,727 Class A-2 common units @ exercise price of $100/Common Unit</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>13307700</totalOfferingAmount>
            <totalAmountSold>13307700</totalAmountSold>
            <totalRemaining>0</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>39</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <signature>
                <issuerName>Lafayette Square Holding Company, LLC</issuerName>
                <signatureName>/s/ Ileana Stone</signatureName>
                <nameOfSigner>Ileana Stone</nameOfSigner>
                <signatureTitle>General Counsel and Head of Compliance</signatureTitle>
                <signatureDate>2024-02-26</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
