SCHEDULE 13G/A 0001193125-23-028474 0001832823 XXXXXXXX LIVE 1 Common Stock, par value $0.0001 per share 03/31/2025 0001854270 Senti Biosciences, Inc. 81726A100 2 Corporate Drive First Floor South San Francisco CA 94080 Rule 13d-1(c) 8VC Fund I, L.P. b DE 0 249827 0 249827 249827 N 1 PN All shares are held of record by 8VC Fund I (as defined in Item 2(a) of the Original Schedule 13G (as defined below)). 8VC GP I (as defined in Item 2(a) of the Original Schedule 13G) is the general partner of 8VC Fund I. Lonsdale (as defined in Item 2(a) of the Original Schedule 13G) is the sole managing member of 8VC GP I and may be deemed to have voting, investment and dispositive power with respect to the shares held by 8VC Fund I. The percentage in Row 11 is based on 26,004,366 shares of Common Stock (as defined in Item 2(d) of the Original Schedule 13G) outstanding as of March 18, 2025, as reported by the Issuer in its annual report on Form 10-K for the year ended December 31, 2024, filed with the Securities and Exchange Commission on March 20, 2025 (the "Form 10-K"). 8VC Entrepreneurs Fund I, L.P. b DE 0 3928 0 3928 3928 N 0 PN All shares are held of record by Entrepreneurs I (as defined in Item 2(a) of the Original Schedule 13G). 8VC GP I is the general partner of Entrepreneurs I. Lonsdale is the sole managing member of 8VC GP I and may be deemed to have voting, investment and dispositive power with respect to the shares held by Entrepreneurs I. The percentage in Row 11 is based on 26,004,366 shares of Common Stock outstanding as of March 18, 2025, as reported by the Issuer in the Form 10-K. 8VC GP I, LLC b DE 0 253755 0 253755 253755 N 1 OO Consists of (i) 249,827 shares of Common Stock held by 8VC Fund I and (ii) 3,928 shares of Common Stock held by Entrepreneurs I. 8VC GP I is the general partner of each of 8VC Fund I and Entrepreneurs I. Lonsdale is the sole managing member of 8VC GP I and may be deemed to have voting, investment and dispositive power with respect to the shares held by each of 8VC Fund I and Entrepreneurs I. The percentage in Row 11 is based on 26,004,366 shares of Common Stock outstanding as of March 18, 2025, as reported by the Issuer in the Form 10-K. Joe Lonsdale b X1 253755 0 253755 0 253755 N 1 IN Consists of (i) 249,827 shares of Common Stock held by 8VC Fund I and (ii) 3,928 shares of Common Stock held by Entrepreneurs I. 8VC GP I is the general partner of each of 8VC Fund I and Entrepreneurs I. Lonsdale is the sole managing member of 8VC GP I and may be deemed to have voting, investment and dispositive power with respect to the shares held by each of 8VC Fund I and Entrepreneurs I. The percentage in Row 11 is based on 26,004,366 shares of Common Stock outstanding as of March 18, 2025, as reported by the Issuer in the Form 10-K. Senti Biosciences, Inc. 2 Corporate Drive, First Floor, South San Francisco, CA, 94080 This Amendment No. 1 (this "Amendment") amends and supplements the Schedule 13G originally filed by the Reporting Persons with the Securities and Exchange Commission on February 8, 2023 (the "Original Schedule 13G"). Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13G remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meaning ascribed to them in the Original Schedule 13G. N See Row 9 of the cover page for each Reporting Person and the corresponding comments.* See Row 11 of the cover page for each Reporting Person and the corresponding comments.* See Row 5 of the cover page for each Reporting Person and the corresponding comments.* See Row 6 of the cover page for each Reporting Person and the corresponding comments.* See Row 7 of the cover page for each Reporting Person and the corresponding comments.* See Row 8 of the cover page for each Reporting Person and the corresponding comments.* *Each of the Reporting Persons disclaims beneficial ownership as to such shares, except to the extent or such Reporting Person's pecuniary interest therein. N Y N N N N N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. 8VC Fund I, L.P. /s/ Joe Lonsdale 05/07/2025 8VC Entrepreneurs Fund I, L.P. /s/ Joe Lonsdale 05/07/2025 8VC GP I, LLC /s/ Joe Lonsdale 05/07/2025 Joe Lonsdale /s/ Joe Lonsdale 05/07/2025