<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-03-23</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001537917</issuerCik>
        <issuerName>TYME TECHNOLOGIES, INC.</issuerName>
        <issuerTradingSymbol>TYME</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001852644</rptOwnerCik>
            <rptOwnerName>Baker Christine D.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TYME TECHNOLOGIES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1 PLUCKEMIN WAY - SUITE 103</rptOwnerStreet2>
            <rptOwnerCity>BEDMINSTER</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07921</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>By: /s/ James Biehl, as attorney-in-fact for Christine D. Baker</signatureName>
        <signatureDate>2022-03-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
