144 0001852129 XXXXXXXX LIVE 0001061983 CYTOKINETICS, INCORPORATED 000-50633 350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 6506243000 ANDREW CALLOS Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

79639 5284047.65 123162807 04/15/2026 NASDAQ Common 04/15/2026 Exercise of Stock Options Issuer N 72190 04/15/2026 Cash Common 03/15/2026 Restricted Stock Units Issuer N 7449 03/15/2026 N/A N 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/31/2026 3639 236535.00 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/18/2026 1930 119803.79 ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/17/2026 8542 530885.30 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/16/2026 1709 104300.27 ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/09/2026 2582 156779.04 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/05/2026 15000 928062.00 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/05/2026 11000 680639.30 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/02/2026 886 54595.32 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 02/05/2026 15000 928927.50 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 02/02/2026 886 55020.60 The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale. 04/15/2026 09/05/2025 /s/ Andrew Callos