X0508 4 2026-03-15 0001061983 CYTOKINETICS INC CYTK 0001852129 Callos Andrew 350 OYSTER POINT BLVD SOUTH SAN FRANCISCO CA 94080 1 EVP, Chief Commercial Officer 0 Common Stock 2026-03-15 4 A 0 20646 0 A 68504 D Common Stock 2026-03-15 4 A 0 13320 0 A 81824 D Incentive Stock Option (Right to Buy) 60.06 2026-03-15 4 A 0 1665 0 A 2026-04-15 2036-03-14 Common Stock 1665 1665 D Non-Qualified Stock Option (Right to Buy) 60.06 2026-03-15 4 A 0 29480 0 A 2026-04-15 2036-03-14 Common Stock 29480 29480 D Annual equity award comprised of restricted stock units ("RSUs") that convert on a 1:1 basis for shares of our common stock. RSUs vest, subject to the officer's continued employment with the company, as follows: 40% of the RSUs on the 1-year anniversary of the grant date, an additional 40% of the RSUs on the 2-year anniversary of the grant date, and the final 20% of the RSUs on the 3-year anniversary of the grant date. RSUs are subject to the company's Amended and Restated 2004 Equity Incentive Plan. Special supplemental equity award comprised of restricted stock units ("RSUs" that convert on a 1:1 basis for shares of our common stock. RSUs vest, subject to the officer's continued employment with the company, as follows: 50% of the RSUs on the 1-year anniversary of the grant date and 50% of the RSUs on the 2-year anniversary of the grant date. RSUs are subject to the company's Amended and Restated 2004 Equity Incentive Plan. Annual equity award comprised of stock options that vest in 48 equal monthly installments, subject to officer's continued employment with the company on each vesting date. Stock options are subject to the company's Amended and Restated 2004 Equity Incentive Plan. Annual equity award comprised of stock options that vest in 48 equal monthly installments, subject to officer's continued employment with the company on each vesting date. Stock options are subject to the company's Amended and Restated 2004 Equity Incentive Plan. /s/ John O. Faurescu, attorney-in-fact for Mr. Callos 2026-03-17