X0508 4 2026-03-02 0001061983 CYTOKINETICS INC CYTK 0001852129 Callos Andrew 350 OYSTER POINT BLVD SOUTH SAN FRANCISCO CA 94080 1 EVP, Chief Commercial Officer 1 Common Stock 2026-03-02 4 M 0 886 37.63 A 51326 D Common Stock 2026-03-02 4 S 0 886 61.62 D 50440 D Incentive Stock Option (Right to Buy) 37.63 2026-03-02 4 M 0 886 0 D 2025-04-01 2032-03-01 Common Stock 886 0 D This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant. /s/ John O. Faurescu, attorney-in-fact for Mr. Callos 2026-03-02