Exhibit 32.1

CERTIFICATIONS OF PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report of Vaxxinity, Inc. (the “Company”) on Form 10-K for the year ended

December 31, 2021 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the

undersigned hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley

Act of 2002, that, to the best of their knowledge:

1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act

of 1934, as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition

and results of operations of the Company.

Date: March 24, 2022 By: /s/ Mei Mei Hu 

 Mei Mei Hu

 President and Chief Executive Officer

(Principal Executive Officer)

Date: March 24, 2022 By: /s/ Jason Pesile 

 Jason Pesile

 Senior Vice President, Finance and Accounting

(Principal Financial and Accounting Officer)