EXHIBIT 31.1

CERTIFICATION

I, Mei Mei Hu, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2021 (the “Report”) of

Vaxxinity , Inc. (the “Registrant”);

2. Based on my knowledge, this Report does not contain any untrue statement of a material fact or omit to state a material fact

necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with

respect to the period covered by this Report;

3. Based on my knowledge, the financial statements, and other financial information included in this Report, fairly present in all

material respects the financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in

this Report;

4. The Registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and

procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)):

a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under

our supervision, to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made

known to us by others within those entities, particularly during the period in which this Report is being prepared;

b) [Paragraph intentionally omitted in accordance with SEC Release Nos. 34-47986 and 34-54942];

c) evaluated the effectiveness of the Registrant’s disclosure controls and procedures and presented in this Report our

conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this

Report based on such evaluation; and

d) disclosed in this Report any change in the Registrant’s internal control over financial reporting that occurred during the

Registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in case of an annual report) that has materially

affected, or is reasonably likely to materially affect, the Registrant’s internal control over financial reporting; and

5. The Registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over

financial reporting, to the Registrant’s auditors and the audit committee of the Registrant’s board of directors (or persons performing

the equivalent functions):

a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting

which are reasonably likely to adversely affect the Registrant’s ability to record, process, summarize and report financial

information; and

b) any fraud, whether or not material, that involves management or other employees who have a significant role in the

Registrant’s internal control over financial reporting.

Date: December 23, 2021

/s/ Mei Mei Hu

Mei Mei Hu

Chief Executive Officer

(principal executive officer)