X0306 4 2021-12-02 0 0001851194 Ventyx Biosciences, Inc. VTYX 0001575202 Gujrathi Sheila C/O VENTYX BIOSCIENCES, INC. 662 ENCINITAS BLVD, SUITE 250 ENCINITAS CA 92024 1 0 0 0 Stock Option (right to buy) 18.65 2021-12-02 4 A 0 277941 0.00 A 2031-12-02 Common Stock 277941 277941 D Subject to the Reporting Person continuing to be a Service Provider (as defined in the Issuer's 2021 Equity Incentive Plan) through each applicable date, one twenty-fourth (1/24th) of the shares subject to the option shall vest each month following the Vesting Commencement Date on the same day of the month as the Vesting Commencement Date (and if there is no corresponding day, on the last day of the month). "Vesting Commencement Date" shall mean December 6, 2021. /s/ Christopher Krueger, as Attorney-in-Fact 2021-12-02