X0306 4 2022-02-17 0 0001357459 PALISADE BIO, INC. PALI 0001850921 Hallam Thomas C/O PALISADE BIO, INC. 5800 ARMADA DR., SUITE 210 CARLSBAD CA 92008 1 1 0 0 Chief Executive Officer Stock Option (right to buy) 0.95 2022-02-17 4 A 0 156600 0.00 A 2032-02-16 Common Stock 156600 156600 D 1/12th of the shares underlying the Stock Option shall vest and become exercisable on each three-month anniversary of the vesting commencement date and if there is no corresponding day, the last day of the month. /s/ JD Finley, Attorney-in-Fact for Thomas Hallam 2022-02-22