X0306 5 2021-12-31 0 0 0 0001850906 Singular Genomics Systems, Inc. OMIC 0001859701 Spaventa Andrew 10931 N. TORREY PINES ROAD SUITE#100 LA JOLLA CA 92037 1 1 0 0 Chief Executive Officer Common Stock 2021-11-04 5 G 0 200000 0.00 D 4413571 I By The Andrew K. Spaventa Living Trust dated April 9, 2014 Common Stock 173144 I By Axon Holdings, LLC This transaction represents a gift by the Reporting Person. The shares are held directly by Axon Holdings, LLC. The managing member of Axon Holdings, LLC is Axon Managers, LLC. The Reporting Person is a managing member of Axon Managers, LLC and may be deemed to have shared voting and investment power over the shares held by Axon Holdings, LLC. The Reporting Person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein. /s/ Dalen Meeter, Attorney-in-Fact 2022-02-11