X0306 4 2021-12-02 0 0001850906 Singular Genomics Systems, Inc. OMIC 0001859701 Spaventa Andrew 10931 N. TORREY PINES ROAD SUITE#100 LA JOLLA CA 92037 1 1 0 0 Chief Executive Officer Common Stock 2021-12-02 4 J 0 715884 D 173144 I By Axon Holdings, LLC Common Stock 4613571 I By The Andrew K. Spaventa Living Trust dated April 9, 2014 The shares were distributed on a pro rata basis by Axon Holdings, LLC. The shares are held directly by Axon Holdings, LLC. The managing member of Axon Holdings, LLC is Axon Managers, LLC. The Reporting Person is a managing member of Axon Managers, LLC. and may be deemed to have shared voting and investment power over the shares held by Axon Holdings, LLC. The Reporting Person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein. /s/ Dalen Meeter, Attorney-in-Fact 2021-12-06