X0306 4 2021-06-01 0 0001850906 Singular Genomics Systems, Inc. OMIC 0001402017 Pellini Michael J 10931 N. TORREY PINES ROAD SUITE#100 LA JOLLA CA 92037 1 0 0 0 Common Stock 2021-05-20 4 C 0 96944 A 96944 I By The Pellini Family Trust Common Stock 72455 D Series A Preferred Stock 2021-05-20 4 C 0 96944 D Common Stock 96944 0 I By The Pellini Family Trust Immediately prior to the closing of the Issuer's initial public offering, each share of the Series A Preferred Stock (the "Preferred Stock") automatically converted into shares of the Issuer's common stock, par value $0.0001 per share, on a one-for-one basis. The shares of Preferred Stock had no expiration date. The Reporting Person is the trustee of The Pellini Family Trust and has voting and dispositive power with respect to these shares. /s/ Dalen Meeter, Attorney-in-Fact 2021-06-01